Novel Cell designed to killing cancer cells.

A novel small molecule(Disarib), designed and synthesised by Indian researchers, has shown promise in targeted killing of cancer cells.
The molecule (Disarib) works by binding itself to a protein called BCL2. While BCL2 protein is produced in excess in cancer cells, its expression is almost undetectable in normal cells.
  • Disarib targets and kills only cancer cells while sparing normal cells
  • expression of BCL2 is low in certain cancer cell lines such as breast cancer, chronic myelogenous leukemia and cervical cancer. So the Disarib molecule would be ineffective in these cancers.
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    Inside a cell there is always a balance between proteins that promote cell death (apoptosis) and those that suppress cell death. Since the proteins (BAX and BAK) that promote cell death get bound to BCL2, normal cell death is suppressed and cancer cells are able to live longer.
    Source: The Hindu

    Synthetic soft tissue retina

    Synthetic soft tissue retina has been developed by Scientists from the University of Oxford
    This soft tissue retina may help to treat degenerative eye conditions such as retinitis pigmentosa. The condition changes how the retina responds to light, causing people to slowly lose vision.

    Our eye is senstitve, due to that we can't use foreign bodies like metal retinal implants as they can damage our/human eye.But a biological synthetic implant is soft and water-based, so much more friendly to the eye environment
    Just as photography depends on camera pixels reacting to light, vision relies on the retina performing the same function.
    The retina sits at the back of the human eye, and contains protein cells that convert light into electrical signals that travel through the nervous system, triggering a response from the brain, ultimately building a picture of the scene being viewed.
    The synthetic, double-layered retina replica consists of soft water droplets (hydrogels) and biological cell membrane proteins.
    Designed like a camera, the cells act as pixels, detecting and reacting to light to create a grey scale image.
    “The synthetic material can generate electrical signals, which stimulate the neurons at the back of our eye just like the original retina,” Ms. Restrepo-Schild said. The study was published in the journal Scientific Reports.